HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 1-Benzhydrylazetidin-3-yl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| Product | 1-Benzhydrylazetidin-3-yl 4-methylbenzenesulfonate | HCID 15512651 | — |
Reaction Steps
1-Benzhydryl-3-hydroxyazetidine is allowed to react with p-toluenesulfonyl chloride using an acid-removing agent to give 1-benzhydryl-3-(p-toluenesulfonyloxy)azetidine. This compound is allowed to react with diethyl malonate in the presence of a base to give diethyl (1-benzhydryl-3-azetidinyl)malonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849757 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-32638a1608284f35961f31aecd80df47 |
| Source note | uspto-grants-1998_12 |