反应详情

A 61.7 g (0.39 mol) portion of ethyl 1-acetylcyclopropanecarboxylate was dissolved in 500 ml of benzene to which were subsequently added 13 g of zinc powder and a catalytically effective amount of iodine. While heating under reflux, a solution of 56.2 ml (0.51 mol) of ethyl bromoacetate in 100 ml of benzene was added dropwise to the mixture above. When the reaction started to progress, the dropwise addition was suspended, 39 g of zinc powder was added in small portions and then the remaining ethyl bromoacetate benzene solution was added dropwise. After completion of the addition, the reaction solution was heated under reflux for another 2 hours. The reaction solution was cooled spontaneously, mixed with 500 ml of 1N hydrochloric acid and then filtered through celite. The organic layer was separated, washed with saturated brine (500 ml×2) and then dried over anhydrous sodium sulfate. By evaporating the solvent, 90.31 g (95%) of the title compound was obtained as an oily substance.

1. temperatureWhile heating
2. temperatureunder reflux
3. additionthe dropwise addition
4. additionAfter completion of the addition
5. temperaturethe reaction solution was heated
6. temperatureunder reflux for another 2 hours
7. temperatureThe reaction solution was cooled spontaneously
8. filtrationfiltered through celite
9. customThe organic layer was separated
10. washwashed with saturated brine (500 ml×2)
11. dry with materialdried over anhydrous sodium sulfate
12. customBy evaporating the solvent