HCID 10979461, compound → HCID 53977651, compound

HRID 1457984Notes

Reaction equation

HRID 1457984 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH2:13][N:12]([C@H:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH3:15])[C:11](=[O:22])[CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H]>[Pt]=O.CO>[CH2:1]([O:3][C:4]([C:6]1([CH:9]2[CH2:13][N:12]([C@H:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH3:15])[C:11](=[O:22])[CH2:10]2)[CH2:7][CH2:8]1)=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 10979461HCID 10979461, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53977651HCID 53977651, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A 13.1 g (43.8 mmol) portion of 4-(1-ethoxycarbonylcyclopropyl)-1-[(S)-1-phenylethyl]-3-pyrrolin-2-one was dissolved 300 ml of methanol, mixed with 400 mg of platinum oxide and then stirred in an atmosphere of hydrogen for 18 hours. After completion of the reaction, the reaction solution was filtered and concentrated to yield 13.0 g (99 %) of the titled compound as an oily substance.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-9bdf700c106e43c1b7ad1e4d40ec9bd7
Source dataset
uspto-grants-1998_12
Patent number
US05849757

Reaction notes

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