反应详情

To 3.40 g (8.91 mmol) of diethyl (1-benzhydryl-3-azetidinyl)malonate dissolved in 30 ml of dichloromethane was added 1.91 ml (13.36 mmol) of benzyl chloroformate, followed by overnight stirring at room temperature. After evaporation of the solvent, the resulting residue was purified by a silica gel column chromatography (250 ml, 3-5% methanol-dichloromethane) to yield 2.64 g (84%) of the title compound.

1. customAfter evaporation of the solvent
2. customthe resulting residue was purified by a silica gel column chromatography (250 ml, 3-5% methanol-dichloromethane)