HCID 22100496, compound → HCID 22100537, compound

HRID 1458001Notes

Reaction equation

HRID 1458001 reaction equation
C(OC([N:11]1[CH2:14][CH:13]([C:15]2([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:16]2)[CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[C].[Pd]>[C:22]([O:21][C:19]([NH:18][C:15]1([CH:13]2[CH2:12][NH:11][CH2:14]2)[CH2:16][CH2:17]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 1

HCID 22100496HCID 22100496, compound

Product 1

HCID 22100537HCID 22100537, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To 1.84 g (5.31 mmol) of 1-benzyloxycarbonyl-3-(1-tert-butoxycarbonylaminocyclopropyl)azetidine dissolved in 100 ml of ethanol was added 1.5 g of 10% palladium-carbon, followed by overnight catalytic hydrogenation at room temperature under normal pressure. After removal of the catalyst by filtration, the solvent was evaporated to yield quantitative amount of the title compound.

Workup

  1. customat room temperature
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-c6864f1e58214735a2fd9597b6cc5107
Source dataset
uspto-grants-1998_12
Patent number
US05849757

Reaction notes

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