反应详情

56 g 2-aminoacetaldehyde dimethyl acetal are dissolved in 200 ml of a 14 wt. % aqueous sodium carbonate solution at 20° C. in a three-necked flask, equipped with a thermometer, reflux condenser, tap funnel and magnetic stirrer. Subsequently, 88 g benzene sulfochloride are added drop-wise within 1 hour at this temperature under intensive stirring followed by another 2 hours of heating the reaction to 40° to 50° C. mixture under vigorous stirring. After that the intensive smell of benzene sulfochloride has disappeared and a second phase has formed. This heavy oily phase is separated in the separatory funnel, imbibed using diethyl ether and dried over water-free sodium sulfate. Once the drying agent has been removed and the ether has been distilled off, 112 g of the product are obtained (yield: 88% based on the amino acetal used).

1. customequipped with a thermometer
2. temperaturereflux condenser, tap funnel and magnetic stirrer
3. temperatureof heating
4. customthe reaction to 40° to 50° C. mixture under vigorous stirring
5. customa second phase has formed
6. customThis heavy oily phase is separated in the separatory funnel
7. dry with materialdried over water-free sodium sulfate
8. customOnce the drying agent has been removed
9. distillationthe ether has been distilled off