2-Chloro-N,N-diethylbenzamide → n,n-Diethyl-2-chloro-6-[tris(1-methylethyl)silyl]benzamide

HRID 1458057Notes

Reaction equation

HRID 1458057 reaction equation
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH:15]([Si:18](Cl)([CH:22]([CH3:24])[CH3:23])[CH:19]([CH3:21])[CH3:20])([CH3:17])[CH3:16]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:18]([CH:22]([CH3:24])[CH3:23])([CH:19]([CH3:21])[CH3:20])[CH:15]([CH3:17])[CH3:16])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

Participants

3

Reactant 2

HCID 825662-Chloro-N,N-diethylbenzamideHCID 139400Triisopropylsilyl chloride

Product 1

HCID 18630226n,n-Diethyl-2-chloro-6-[tris(1-methylethyl)silyl]benzamide

Procedure

The title compound was prepared according to General Method A from the compound of Example e and 1.1 eq triisopropylsilyl chloride. Purification by HPLC using 1:19 ethyl acetate/hexanes gave 5.5 g of the desired product as of a clear oil, a 75% yield.

Workup

  1. customThe title compound was prepared
  2. customPurification by HPLC

Sources & evidence

ORD record
ord-d1bf932bbaec40f4a1c51f9cd4f4f913
Source dataset
uspto-grants-1998_12
Patent number
US05849723

Reaction notes

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