Propargylamine → HCID 18630371, compound

HRID 1458115Notes

Reaction equation

HRID 1458115 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]=1[C:4](Cl)=[O:5].[CH2:15]([NH2:18])[C:16]#[CH:17]>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]=1[C:4]([NH:18][CH2:15][C:16]#[CH:17])=[O:5]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 18630170HCID 18630170, compound

Product 1

HCID 18630371HCID 18630371, compoundYield 81%

Procedure

The compound of Example d was reacted with propargylamine (3 eq) according to General Method E1 and the crude product was recrystallized from hexanes to afford 0.55 g of the title compound as off-white needles in 81% yield. m.p. 120°-121° C.

Workup

  1. customthe crude product was recrystallized from hexanes

Sources & evidence

ORD record
ord-2ccedcd6d4714fadb563730c4c74b824
Source dataset
uspto-grants-1998_12
Patent number
US05849723

Reaction notes

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