Water → HCID 85746660, compound

HRID 1458190Notes

Reaction equation

HRID 1458190 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[N:6]([C:14]([CH3:19])([CH3:18])[C:15]([O-:17])=O)=[N:7][C:8]([CH3:13])([CH3:12])[C:9]([O-:11])=O.C[O-].[Na+].O>CO>[N:7]([C:8]([CH3:12])([CH3:13])[C:9]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:11])=[N:6][C:14]([CH3:19])([CH3:18])[C:15]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:17]

Participants

6

Reactant 4

HCID 962WaterHCID 6558IsobutylamineHCID 10942334Sodium MethoxideHCID 22022530HCID 22022530, compound

Product 1

HCID 85746660HCID 85746660, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
10 °C

Procedure

34.9 Grams of isobutylamine is mixed with 50 g of 2,2'-azobis (2-methyl propionate), and 10 g of 28% sodium methoxide solution in methanol is dropwise added thereto with stirring, followed by conducting a reaction at room temperature with stirring for 6 hours and keeping standing overnight. 100 Milliliter of water is added to the reaction solution and cooled to 10° C. to precipitate crystals. The crystals are recovered by filtration and dried to give 56.4 g (yield 83%) of 2,2'-azobis [N-(2 -methylpropyl)-2-methyl propionamide] as pale yellow crystal. The solubility is shown in Table 1.

Workup

  1. additionis dropwise added
  2. customa reaction at room temperature
  3. stirringwith stirring for 6 hours
  4. customto precipitate crystals
  5. filtrationThe crystals are recovered by filtration
  6. customdried

Sources & evidence

ORD record
ord-2a02c6b6e85a42b58b4d7bb52176c9df
Source dataset
uspto-grants-1998_12
Patent number
US05849888

Reaction notes

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