Water → HCID 22936069, compound

HRID 1458192Notes

Reaction equation

HRID 1458192 reaction equation
[CH2:1]([NH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[N:8]([C:16]([CH3:21])([CH3:20])[C:17]([O-:19])=O)=[N:9][C:10]([CH3:15])([CH3:14])[C:11]([O-:13])=O.C[O-].[Na+].O>CO.CCCCCC>[N:9]([C:10]([CH3:14])([CH3:15])[C:11]([NH:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[O:13])=[N:8][C:16]([CH3:21])([CH3:20])[C:17]([NH:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[O:19]

Participants

7

Reactant 4

HCID 962WaterHCID 8102HexylamineHCID 10942334Sodium MethoxideHCID 22022530HCID 22022530, compound

Product 1

HCID 22936069HCID 22936069, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 8058HexaneSolvent

Procedure

28.2 Grams of n-hexylamine is mixed with 50 g of 2,2'-azobis (2-methyl propionate), and 20 g of 28% sodium methoxide solution in methanol and 10 ml of methanol are added thereto with stirring followed by conducting a reaction at room temperature with stirring for 6 hours and keeping standing overnight. 100 Milliliter of water is added to the reaction solution and extraction with 100 ml of n-hexane is conducted. The hexane layer is washed with water and dried over anhydrous sodium sulfate. The solvent is removed by distillation to give 76.3 g (yield 95%) of 2,2'-azobis (N-hexyl-2-methyl propionamide) as pale yellow sintering crystal. The solubility is shown in Table 1.

Workup

  1. additionare added
  2. customa reaction at room temperature
  3. stirringwith stirring for 6 hours
  4. washThe hexane layer is washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent is removed by distillation

Sources & evidence

ORD record
ord-9bf436d0395e457ca178dd22b161816b
Source dataset
uspto-grants-1998_12
Patent number
US05849888

Reaction notes

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