Pyridine → HCID 53801641, compound

HRID 1458221Notes

Reaction equation

HRID 1458221 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][C:6]1[N:7]=[CH:8][S:9][C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12].N1C=CC=CC=1>ClCCl>[C:1]([O:12][CH:11]([C:10]1[S:9][CH:8]=[N:7][C:6]=1[CH3:5])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 22101805HCID 22101805, compound

Product 1

HCID 53801641HCID 53801641, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (0.6 ml) was added to a solution of 1-(4-methyl-5-thiazolyl) -1-phenylmethanol (800 mg) and pyridine (0.5 ml) in dichloromethane (30 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was allowed to warm room temperature and was then stirred overnight. Evaporation and purification of the residue by flash chromatography gave the title compound.

Workup

  1. customEvaporation and purification of the residue by flash chromatography

Sources & evidence

ORD record
ord-013f25c79ae5421887108219013dde81
Source dataset
uspto-grants-1998_12
Patent number
US05849921

Reaction notes

Loading…