HCID 22101833, compound → HCID 22101855, compound

HRID 1458222Notes

Reaction equation

HRID 1458222 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)[OH:8]>[Pd].C(O)C>[NH2:15][C:11]1[CH:10]=[C:9]([CH:7]([C:6]2[S:5][CH:4]=[N:3][C:2]=2[CH3:1])[OH:8])[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 22101833HCID 22101833, compound

Product 1

HCID 22101855HCID 22101855, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(4-Methyl-5-thiazolyl)-1-(3-nitrophenyl)methanol (2 g) and 10% palladium on charcoal (200 mg) in ethanol (60 ml) were shaken overnight under an atmosphere of hydrogen. The mixture was filtered and the filtrate was evaporated to dryness. The residue was converted into the hydrochloride salt, recrystallised and then reconverted into the title compound. M.p. 137°-138° C.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness
  3. customrecrystallised

Sources & evidence

ORD record
ord-916174986bff4b458eaf3fefe20b61a4
Source dataset
uspto-grants-1998_12
Patent number
US05849921

Reaction notes

Loading…