Acetyl chloride → HCID 22101836, compound

HRID 1458226Notes

Reaction equation

HRID 1458226 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][C:6]1[N:7]=[CH:8][S:9][C:10]=1[CH:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N(CC)CC)C>ClCCl>[CH3:5][C:6]1[N:7]=[CH:8][S:9][C:10]=1[CH:11]([NH:18][C:1](=[O:3])[CH3:2])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 9881256HCID 9881256, compound

Product 1

HCID 22101836HCID 22101836, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride was added to a solution of the product from Example 56 and triethylamine in dry dichloromethane. The mixture was stirred at room temperature overnight and then washed with aqueous sodium hydrogen carbonate solution. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound.

Workup

  1. washwashed with aqueous sodium hydrogen carbonate solution
  2. customThe organic phase was separated
  3. customdried
  4. customevaporated
  5. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-6555bebf17ec47bbaad06ba6f78d7e21
Source dataset
uspto-grants-1998_12
Patent number
US05849921

Reaction notes

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