Water → N-[4-(Pentafluorosulfanyl)phenyl]acetamide

HRID 1458281Notes

Reaction equation

HRID 1458281 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([F:20])([F:19])([F:18])([F:17])[F:16])=[CH:11][CH:10]=1.O>C(O)(=O)C>[C:5]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([F:20])([F:16])([F:17])([F:18])[F:19])=[CH:11][CH:10]=1)(=[O:7])[CH3:6]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27791904-Aminophenylsulphur pentafluoride

Product 1

HCID 21576972N-[4-(Pentafluorosulfanyl)phenyl]acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
65 °C

Procedure

Acetic anhydride was added during 5 minutes to a stirred solution of 4-aminophenylsulphur pentafluoride (30.2 g) in acetic acid at 40° C. and then heated at 65° C. for 0.5 hour. The cooled mixture was added to water, stirred for 1 hour and filtered. The solid was washed with water, sodium bicarbonate solution and water, dried and purified by stirring with hexane to give 4-acetamidophenylsulphur pentafluoride (27.0 g), m.p.131°-132° C.

Workup

  1. filtrationfiltered
  2. washThe solid was washed with water, sodium bicarbonate solution and water
  3. customdried
  4. custompurified
  5. stirringby stirring with hexane

Sources & evidence

ORD record
ord-229c361bfc174557bb83b35e44524864
Source dataset
uspto-grants-1998_12
Patent number
US05849928

Reaction notes

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