反应详情

2-geranyloxybenzoic acid (1.36 g) was dissolved in dichloromethan (20 ml) and 1-hydroxybenzotriazole (0.80 g) and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (1.14 g) were added thereto while being cooled with ice. After the resulting mixture was stirred for 30 minutes, 4-amino-1,2-diethyl pyrazolidine (0.71 g) was added thereto and the mixture was stirred for one night at room temperature. The reaction liquid was washed with brine and then dried over sodium sulfite anhydride. Thereafter, the solvent was evaporated under a vacuum. The residue was purified by silica gel column-m chromatography (chloroform:methanol=30:1), thereby yielding 1.71 g (87%) of the aimed compound.

1. temperaturewhile being cooled with ice
2. stirringthe mixture was stirred for one night at room temperature
3. customThe reaction liquid
4. washwas washed with brine
5. dry with materialdried over sodium sulfite anhydride
6. customThereafter, the solvent was evaporated under a vacuum
7. customThe residue was purified by silica gel column-m chromatography (chloroform:methanol=30:1)