HRID1458375

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCN(CCCCc3ccncc3)C(=O)OC(C)(C)C)c2c1

HCID86753453

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)O)cc3c2CCN(CCCCc2ccncc2)C(=O)OC(C)(C)C)c1

HCID22100876

未命名化合物

PROCEDURE

实验过程

Prepared essentially as described in Example 9.1 Step B starting from 3-{2-[tert-butoxycarbonyl-(4-pyridin-4-yl-butyl)-amino]-ethyl}-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester and using lithium hydroxide to give the title compound.

WORKUP

后处理

customPrepared essentially

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-459c954f08dd4df59fed036292d318d9
来源数据集: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05849764
来源说明: uspto-grants-1998_12

反应 SMILES

C([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]([C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[C:17]([CH3:22])[CH:16]=1)=[C:9]2[CH2:23][CH2:24][N:25]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:26][CH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=1)=[O:5])C.[OH-].[Li+]>>[C:39]([O:38][C:36]([N:25]([CH2:26][CH2:27][CH2:28][CH2:29][C:30]1[CH:31]=[CH:32][N:33]=[CH:34][CH:35]=1)[CH2:24][CH2:23][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=2)[NH:11][C:10]=1[C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[C:17]([CH3:22])[CH:16]=1)=[O:37])([CH3:42])([CH3:40])[CH3:41]