Beta-Alanine → HCID 22483843, compound

HRID 1458495Notes

Reaction equation

[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[CH2:3].[NH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]>>[C:1]([NH:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])(=[O:5])[C:2]([CH3:4])=[CH2:3]

Participants

Reactant 2

HCID 239Beta-Alanine

HCID 13528Methacryloyl chloride

Product 1

HCID 22483843HCID 22483843, compound

Procedure

Methacryloyl chloride was reacted with β-alanine to give N-methacryloyl β-alanine which was further reacted with p-nitro aniline to obtain N-methacryloyl β-alanyl p-nitro anilide. N-isobutyryl β-alanyl 2-amino pyridine was used as the print molecule, 0.5 gm (0.0021 mol) N-isobutyryl β-alanyl 2-amino pyridine, 0.468 gm (0.0021 mol) N-methacryloyl histidine, and 0.124 gm (0.0021 mol) CoCl2.6H2O were placed in 5 ml methanol and stirred for 1 hour. Methanol was evaporated under reduced pressure. The complex was diluted with 3.9 gm 2-hydroxyethyl methacrylate, 0.8 ml t-butyl hydroperoxide was added, and the mixture polymerized at 65° C. for 16 hours.

Sources & evidence

ORD record: ord-9c912c8356f045a5ab5cdad73c576706
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05851546

Reaction notes

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