3-Chloropropyl(diethyl)amine → HCID 178463983, compound

HRID 1458509Notes

Reaction equation

HRID 1458509 reaction equation
[Cl-].[Zn+2:2].[Cl-].[CH2:4]([N:6]([CH2:11][CH3:12])[CH2:7][CH2:8][CH2:9]Cl)[CH3:5]>O1CCCC1>[CH2:4]([N:6]([CH2:11][CH3:12])[CH2:7][CH2:8][CH2:9][Zn:2][CH2:9][CH2:8][CH2:7][N:6]([CH2:11][CH3:12])[CH2:4][CH3:5])[CH3:5]

Participants

4

Reactant 2

HCID 669183-Chloropropyl(diethyl)amineHCID 3007855Zincchloride

Product 1

HCID 178463983HCID 178463983, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

6.8 g (0.05 mol) of zinc chloride in 100 ml of tetrahydrofuran are added at room temperature to a Grignard reagent prepared from 4.9 g (0.2 mol) of Mg and 19.4 g (0.16 mol) of 3-diethylaminopropyl chloride in 100 ml of tetrahydrofuran. When the reaction has ended, the mixture is stirred at room temperature for 24 hours and filtered, the solvent is removed and the residue is distilled in vacuo. Bis(3-diethylaminopropyl)zinc is obtained as a colourless liquid having a boiling point of 103° C./0.1 mbar.

Workup

  1. filtrationfiltered
  2. customthe solvent is removed
  3. distillationthe residue is distilled in vacuo

Sources & evidence

ORD record
ord-c02eaa92f9fa4f5698a30fa61cbbb445
Source dataset
uspto-grants-1998_12
Patent number
US05851946

Reaction notes

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