Methyl iodide → HCID 22097036, compound

HRID 1458553Notes

Reaction equation

[CH3:1]C(C)([O-])C.[K+].[Cl:7][C:8]1[C:9]([NH:23][S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[C:10]2[C:15](=[CH:16][C:17]=1[Cl:18])[N:14]=[C:13]([O:19][CH3:20])[C:12]([O:21][CH3:22])=[N:11]2.CI>CN(C)C=O>[Cl:7][C:8]1[C:9]([N:23]([CH3:1])[S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[C:10]2[C:15](=[CH:16][C:17]=1[Cl:18])[N:14]=[C:13]([O:19][CH3:20])[C:12]([O:21][CH3:22])=[N:11]2

Participants

Conditions

Temperature: 20 °C

Procedure

Potassium tert-butoxide (67.5 mg, 1.1 mmol) was added to a stirred solution of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)ethanesulphonamide (Preparation 4) (200 mg, 0.55 mmol) in dry dimethylformamide (3 ml) under nitrogen at 20° C. After 5 minutes, methyl iodide (38 μl, 1.1 mmol) was added and the mixture was stirred at 20° C. for 2 hours. The mixture was concentrated under reduced pressure, partitioned between ethyl acetate and water, and the combined organic extracts were washed with dilute aqueous sodium hydroxide. The solution was dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash chromatography (eluting with dichloromethane) to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(methyl)ethanesulphonamide (150 mg, 79%).

Workup

concentrationThe mixture was concentrated under reduced pressure
custompartitioned between ethyl acetate and water
washthe combined organic extracts were washed with dilute aqueous sodium hydroxide
dry with materialThe solution was dried (MgSO4)
concentrationconcentrated under reduced pressure
customThe residue was purified by flash chromatography (eluting with dichloromethane)

Sources & evidence

ORD record: ord-a762b4163d8e413689e1ba08022c6ec5
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05852016

Reaction notes

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