Hydrochloric Acid → HCID 22097029, compound

HRID 1458554Notes

Reaction equation

HRID 1458554 reaction equation
[Cl:1][C:2]1[C:3]([N:17]([CH3:23])[S:18]([CH2:21][CH3:22])(=[O:20])=[O:19])=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([O:13]C)[C:6]([O:15]C)=[N:5]2.Cl>O1CCOCC1>[Cl:1][C:2]1[C:3]([N:17]([CH3:23])[S:18]([CH2:21][CH3:22])(=[O:20])=[O:19])=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[NH:8][C:7](=[O:13])[C:6](=[O:15])[NH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22097036HCID 22097036, compound

Product 1

HCID 22097029HCID 22097029, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(methyl)-ethanesulphonamide (150 mg, 0.39 mmol), 2M hydrochloric acid (4 ml) and dioxane (8 ml) was heated at reflux for 16 hours, cooled, and concentrated under reduced pressure. The solid residue was suspended in water, filtered off, and washed with water and ether to give the title compound (140 mg, 99%) as a white solid, m.p. >300° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. temperaturecooled
  4. concentrationconcentrated under reduced pressure
  5. filtrationfiltered off
  6. washwashed with water and ether

Sources & evidence

ORD record
ord-1730f4c3b27c4ef2b027bd9fbf57ba8d
Source dataset
uspto-grants-1998_12
Patent number
US05852016

Reaction notes

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