Hydrochloric Acid → HCID 22097041, compound

Participants

Reaction Steps

A mixture of N-(3-amino-6-chloro-7-trifluoromethyl-2-methoxyquinoxalin-5-yl)-N-ethyl-methanesulphonamide (step (a) above, 70 mg, 0.18 mmol), 2M hydrochloric acid (3 ml) and dioxane (6 ml) was heated at reflux for 2 h, cooled and concentrated under reduced pressure. The residue was suspended in water, filtered and the solid was washed with water. After being dried, the title compound (33 mg, 48%) was obtained as a white solid, m.p. >300° C.

Provenance & Evidence