Hydrochloric Acid → HCID 22097041, compound

HRID 1458558Notes

Reaction equation

HRID 1458558 reaction equation
N[C:2]1[C:3]([O:24]C)=[N:4][C:5]2[C:10]([N:11]=1)=[C:9]([N:12]([CH2:17][CH3:18])[S:13]([CH3:16])(=[O:15])=[O:14])[C:8]([Cl:19])=[C:7]([C:20]([F:23])([F:22])[F:21])[CH:6]=2.Cl.[O:27]1CCOCC1>>[Cl:19][C:8]1[C:9]([N:12]([CH2:17][CH3:18])[S:13]([CH3:16])(=[O:15])=[O:14])=[C:10]2[C:5](=[CH:6][C:7]=1[C:20]([F:21])([F:22])[F:23])[NH:4][C:3](=[O:24])[C:2](=[O:27])[NH:11]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 22097014HCID 22097014, compound

Product 1

HCID 22097041HCID 22097041, compoundYield 48%

Procedure

A mixture of N-(3-amino-6-chloro-7-trifluoromethyl-2-methoxyquinoxalin-5-yl)-N-ethyl-methanesulphonamide (step (a) above, 70 mg, 0.18 mmol), 2M hydrochloric acid (3 ml) and dioxane (6 ml) was heated at reflux for 2 h, cooled and concentrated under reduced pressure. The residue was suspended in water, filtered and the solid was washed with water. After being dried, the title compound (33 mg, 48%) was obtained as a white solid, m.p. >300° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 h
  3. temperaturecooled
  4. concentrationconcentrated under reduced pressure
  5. filtrationfiltered
  6. washthe solid was washed with water
  7. customAfter being dried

Sources & evidence

ORD record
ord-e0ec4d072c4b4a50b3c608f592b83b61
Source dataset
uspto-grants-1998_12
Patent number
US05852016

Reaction notes

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