Hydrochloric Acid → HCID 54321377, compound

HRID 1458571Notes

Reaction equation

HRID 1458571 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54103043HCID 54103043, compound

Product 1

HCID 54321377HCID 54321377, compoundYield 84%

Procedure

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxyquinoxaline (from step (a), 12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH3) and the solid which precipitated was filtered off, washed with water and ether, and dried in vacuo at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, m.p. 225°-227° C.

Workup

  1. customthe solid which precipitated
  2. filtrationwas filtered off
  3. washwashed with water and ether
  4. customdried in vacuo at 80° C.

Sources & evidence

ORD record
ord-8d770f62e6524feb864f26d52013763e
Source dataset
uspto-grants-1998_12
Patent number
US05852016

Reaction notes

Loading…