Hydrochloric Acid → HCID 10823051, compound

HRID 1458574Notes

Reaction equation

HRID 1458574 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[C:5]([Cl:10])=[CH:4][C:3]=1[NH2:11].[C:12](O)(=[O:16])[C:13](O)=[O:14].Cl>>[Cl:10][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][C:6]=1[CH2:8][CH3:9])[NH:1][C:13](=[O:14])[C:12](=[O:16])[NH:11]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 971Oxalic AcidHCID 10631005HCID 10631005, compound

Product 1

HCID 10823051HCID 10823051, compoundYield 80.1%

Procedure

A mixture of 1,2-diamino-4-chloro-5-ethylbenzene (from (a), 2.70 g, ca 13 mmol), oxalic acid (1.65 g, 18.3 mmol) and 4M hydrochloric acid (66 ml) was heated at reflux for 4.6 h, cooled, and the grey solid collected by filtration and washed with water. The solid was dried in vacuo at 50° C. to afford the title compound (2.34 g, 80%), m.p. >315° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4.6 h
  3. temperaturecooled
  4. filtrationthe grey solid collected by filtration
  5. washwashed with water
  6. customThe solid was dried in vacuo at 50° C.

Sources & evidence

ORD record
ord-f85c5462d7b44737aa8461e07e6429b2
Source dataset
uspto-grants-1998_12
Patent number
US05852016

Reaction notes

Loading…