Diethyl Oxalate → 6-Chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione

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Reaction Steps

A mixture of 1,2-diamino-4-chloro-5-trifluoromethylbenzene (13.4 g, 63.6 mmol) and diethyl oxalate (100 ml) was heated at reflux under nitrogen with stirring for 5 h. After being cooled, the solid which formed was filtered off and washed well with ether to afford a pale orange solid (14.5 g, 86%).

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