Hydrochloric Acid → HCID 178524756, compound

HRID 1458634Notes

Reaction equation

HRID 1458634 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([O:12]CC)=[O:11])=[CH:5][N:4]=1.[OH-].[Na+].Cl>O>[F:16][C:2]([F:1])([F:15])[C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([OH:12])=[O:11])=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469779HCID 178469779, compound

Product 1

HCID 178524756HCID 178524756, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of ethyl 2-trifluoromethyl-4-hydroxypyrimidine-5-carboxylate (5.00 g, 19.4 mmol) and NaOH (0.93 g, 23.3 mmol) in H2O (20 mL) was stirred at 60° C. for 15 h. The reaction was acidified (conc. HCl) and concentrated until a solid began to form. The solid was filtered and dried to give 2-trifluoromethyl-4-hydroxypyrimidine-5-carboxylic acid (2.1 g, 53% yield); 1HNMR (DMSO-d6) δ 8.83 (s, 1H).

Workup

  1. concentrationconcentrated until a solid
  2. customto form
  3. filtrationThe solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-eb142d0e53a14329b44a92f293d8ed92
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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