Hydrazine → HCID 2781895, compound

HRID 1458636Notes

Reaction equation

HRID 1458636 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[NH2:17][NH2:18]>C1COCC1>[NH:17]([C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)[NH2:18]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 2737166Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate

Product 1

HCID 2781895HCID 2781895, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate (0.20 g, 0.79 mmol), hydrazine (0.18 g, 6.0 mmol) and THF was stirred for 1 h at room temperature. The solution was filtered and dried to give the title compound in a 96% yield; 1HNMR (CDCl3) δ 9.26 (s, 1H), 8.90 (s, 1H), 4.40 (q, 2H), 4.24 (bs, 2H), 1.41 (t, 3H).

Workup

  1. filtrationThe solution was filtered
  2. customdried

Sources & evidence

ORD record
ord-44e0c9429d0742f381c1639feb18af0e
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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