Hydrazine → HCID 21220651, compound

HRID 1458639Notes

Reaction equation

HRID 1458639 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1.[NH2:20][NH2:21]>C1COCC1>[NH:20]([C:2]1[N:7]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1)[NH2:21]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21220601HCID 21220601, compound

Product 1

HCID 21220651HCID 21220651, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as described in Example 18, but employing a solution of ethyl 2-chloro-4-pentafluoroethylpyrimidine-5-carboxylate (0.30 g, 0.99 mmol) and hydrazine (0.16 g, 5.0 mmol) in THF (20 mL) resulting in a 95% yield (0.28 g); 1HNMR (CDCl3) δ 8.86 (bs, 1H), 7.12 (bs, 1H), 4.37 (q, 2H), 1.72 (bs, 2H), 1.38 (t, 3H).

Workup

  1. customresulting in a 95% yield (0.28 g)

Sources & evidence

ORD record
ord-a45eb307c9564900b92e7b5fce63685b
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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