Hydrazine → HCID 21220615, compound

HRID 1458640Notes

Reaction equation

HRID 1458640 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:4][N:3]=1.[NH2:19][NH2:20]>C1COCC1>[NH:19]([C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:4][N:3]=1)[NH2:20]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 10849112HCID 10849112, compound

Product 1

HCID 21220615HCID 21220615, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as described in Example 18, but employing a solution of ethyl 2-chloro-4-phenylpyrimidine-5-carboxylate (0.09 g, 0.34 mmol) and hydrazine (0.06 g, 1.7 mmol) in THF resulting in a 91% yield (0.08 g); m.p. 74°-75° C.

Sources & evidence

ORD record
ord-1341f26549d44e938bb855b43bafab09
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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