Hydrazine → HCID 21220622, compound

HRID 1458641Notes

Reaction equation

HRID 1458641 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1.[NH2:20][NH2:21]>C1COCC1>[NH:20]([C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1)[NH2:21]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21220675HCID 21220675, compound

Product 1

HCID 21220622HCID 21220622, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as described in Example 18, but employing a solution of ethyl 2-chloro-4-benzylpyrimidine-5-carboxylate (0.34 g, 1.2 mmol) and hydrazine (0.2 g, 6.1 mmol) in THF resulting in a 99% yield (0.33 g, oil); GC/MS, 272(M+).

Sources & evidence

ORD record
ord-6c0918807c4c4e6f97183c49b289cd05
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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