Phosphorus oxychloride → HCID 21220675, compound

HRID 1458642Notes

Reaction equation

HRID 1458642 reaction equation
O[C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178469853HCID 178469853, compound

Product 1

HCID 21220675HCID 21220675, compoundYield 37%

Procedure

The title compound was prepared as described in Example 7, but employing a solution of ethyl 2-hydroxy-4-benzylpyrimidine-5-carboxylate (1.1 g, 4.3 mmol) and POCl3 (16 g, 107 mmol) resulting in a 37% yield (0.44 g); 1HNMR (DMSO-d6) δ 9.00 (s, 1H), 7.6-7.4 (m, 5H), 4.55 (s, 2H), 4.25 (q, 2H), 1.14 (t, 3H).

Workup

  1. customresulting in a 37% yield (0.44 g)

Sources & evidence

ORD record
ord-0711928bd8ce4377b662bdf7f16b4a4f
Source dataset
uspto-grants-1998_12
Patent number
US05852028

Reaction notes

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