反应详情

7.25 g (30 mmol) of 4-chloro-5-iodo-5-ethylpyrimidine (EP 470 600), 5.6 g (36 mmol) of cis-4-tert-butylcyclohexylamine and 6.1 g of triethylamine were heated at from 80° to 90° C. for 4 hours without solvent. After cooling, the mixture was taken up in water/toluene and the organic phase was dried and concentrated. The crude product was purified by chromatography on silica gel using petroleum ether/ethyl acetate (7:3), to give 7.4 g (56.7% of theory) of a yellow oil.

1. temperatureAfter cooling
2. customthe organic phase was dried
3. concentrationconcentrated
4. customThe crude product was purified by chromatography on silica gel
5. customto give 7.4 g (56.7% of theory) of a yellow oil