Potassium Hydroxide → HCID 178436601, compound

HRID 1458649Notes

Reaction equation

HRID 1458649 reaction equation
[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12]2[C:17]([C:18]#[C:19][Si](C)(C)C)=[C:16]([CH2:24][CH3:25])[N:15]=[CH:14][N:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>CO>[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12]2[C:17]([C:18]#[CH:19])=[C:16]([CH2:24][CH3:25])[N:15]=[CH:14][N:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178437718HCID 178437718, compound

Product 1

HCID 178436601HCID 178436601, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.8 g (7.7 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-6-ethyl-5-(trimethylsilylethynyl)pyrimidine (Example 7) were stirred in 25 ml of a 0.4 molar solution of potassium hydroxide in methanol at room temperature for 4 hours. The mixture was concentrated, the residue was taken up in toluene/water and the organic phase was dried and concentrated to leave 1.85 g (84.2% of theory) of a colorless solid.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe organic phase was dried
  3. concentrationconcentrated
  4. customto leave 1.85 g (84.2% of theory) of a colorless solid

Sources & evidence

ORD record
ord-a8a7e02633744dfa8eecb23d9be5b9ad
Source dataset
uspto-grants-1998_12
Patent number
US05852023

Reaction notes

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