Potassium Hydroxide → HCID 178436601, compound

Participants

Reaction Steps

2.8 g (7.7 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-6-ethyl-5-(trimethylsilylethynyl)pyrimidine (Example 7) were stirred in 25 ml of a 0.4 molar solution of potassium hydroxide in methanol at room temperature for 4 hours. The mixture was concentrated, the residue was taken up in toluene/water and the organic phase was dried and concentrated to leave 1.85 g (84.2% of theory) of a colorless solid.

Provenance & Evidence