Trimethylsilylacetylene → HCID 178437715, compound

HRID 1458651Notes

Reaction equation

[CH2:1]([C:3]1[N:8]=[CH:7][N:6]=[C:5]([NH:9][C@H:10]2[CH2:15][CH2:14][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[C:4]=1I)[CH3:2].[CH3:23][Si:24]([C:27]#[CH:28])([CH3:26])[CH3:25]>>[CH2:1]([C:3]1[N:8]=[CH:7][N:6]=[C:5]([NH:9][C@H:10]2[CH2:15][CH2:14][C@@H:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[C:4]=1[C:28]#[C:27][Si:24]([CH3:26])([CH3:25])[CH3:23])[CH3:2]

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 178437716HCID 178437716, compound

Product 1

HCID 178437715HCID 178437715, compound

Procedure

Prepared as in Example 7 from 6-ethyl-5-iodo-4-(cis-4-phenylcyclohexylamino)pyrimidine (Example 8) and trimethylsilylacetylene (colorless solid).

Sources & evidence

ORD record: ord-0d16ef84fcc445aeb7cf9aabd1362ae1
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05852023

Reaction notes

Loading…