Ethylene → HCID 178436602, compound

Participants

Reaction Steps

3.9 g (10 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-6-ethyl-5-iodopyrimidine (Example 1) were treated with 10 bar of ethylene in an autoclave at 120° C. in the presence of 1.5 g (15 mmol) of potassium acetate and 50 mg of palladium black in 100 ml of methanol. After 24 hours, the catalyst was removed by filtration and the mixture was concentrated. Chromatography on silica gel gave 1.70 g (61.8% of theory) of colorless oil.

Provenance & Evidence