反应详情

3.9 g (10 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-6-ethyl-5-iodopyrimidine (Example 1) were treated with 10 bar of ethylene in an autoclave at 120° C. in the presence of 1.5 g (15 mmol) of potassium acetate and 50 mg of palladium black in 100 ml of methanol. After 24 hours, the catalyst was removed by filtration and the mixture was concentrated. Chromatography on silica gel gave 1.70 g (61.8% of theory) of colorless oil.

1. customthe catalyst was removed by filtration
2. concentrationthe mixture was concentrated
3. customChromatography on silica gel gave 1.70 g (61.8% of theory) of colorless oil