Triethylamine → HCID 178456122, compound

HRID 1458658Notes

Reaction equation

HRID 1458658 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[C:6]([CH:9]([Cl:11])[CH3:10])[N:5]=[CH:4][N:3]=1.[C:12]([C@@H:16]1[CH2:21][CH2:20][C@H:19]([NH2:22])[CH2:18][CH2:17]1)([CH3:15])([CH3:14])[CH3:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:12]([C@@H:16]1[CH2:17][CH2:18][C@H:19]([NH:22][C:2]2[C:7]([Cl:8])=[C:6]([CH:9]([Cl:11])[CH3:10])[N:5]=[CH:4][N:3]=2)[CH2:20][CH2:21]1)([CH3:15])([CH3:13])[CH3:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 189828684,5-Dichloro-6-(1-chloroethyl)pyrimidineHCID 178445676HCID 178445676, compound

Product 1

HCID 178456122HCID 178456122, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

32.3 g (0.15 mol) of 4,5-dichloro-6-(1-chloroethyl)pyrimidine(EP 543 402) were stirred in 200 ml of toluene with 23.3 g (0.15 mol) of cis-4-tert-butylcyclohexylamine and 20.2 g (0.20 mol) of triethylamine at from 80° to 90° C. for 6 hours. The mixture was extracted by stirring with water and the organic phase was dried and concentrated. The residue was purified by chromatography on silica gel, to give 36.3 g (73.2% of theory) of a colorless oil.

Workup

  1. extractionThe mixture was extracted
  2. customthe organic phase was dried
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography on silica gel
  5. customto give 36.3 g (73.2% of theory) of a colorless oil

Sources & evidence

ORD record
ord-1f0f88e4a3764ccf8a517e03227d7e08
Source dataset
uspto-grants-1998_12
Patent number
US05852023

Reaction notes

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