反应详情

32.3 g (0.15 mol) of 4,5-dichloro-6-(1-chloroethyl)pyrimidine(EP 543 402) were stirred in 200 ml of toluene with 23.3 g (0.15 mol) of cis-4-tert-butylcyclohexylamine and 20.2 g (0.20 mol) of triethylamine at from 80° to 90° C. for 6 hours. The mixture was extracted by stirring with water and the organic phase was dried and concentrated. The residue was purified by chromatography on silica gel, to give 36.3 g (73.2% of theory) of a colorless oil.

1. extractionThe mixture was extracted
2. customthe organic phase was dried
3. concentrationconcentrated
4. customThe residue was purified by chromatography on silica gel
5. customto give 36.3 g (73.2% of theory) of a colorless oil