反应详情

58.6 g (0.39 mol) of 4,6-dichloropyrimidine were placed in 400 ml of toluene, and a mixture of 61.0 g (0.39 mol) of cis-4-tert-butylcyclohexylamine and 50.0 g (0.50 mol) of triethylamine in 100 ml of toluene was added dropwise at from 70° to 80° C. The mixture was subsequently stirred at reflux for 4 hours. After cooling, it was extracted by stirring with water, the organic phase was dried and concentrated, to give a colorless oil which crystallized after trituration with petroleum ether. Filtration with suction left 70.5 g (67.0% of theory) of colorless crystals.

1. additionwas added dropwise at from 70° to 80° C
2. temperatureat reflux for 4 hours
3. temperatureAfter cooling
4. extractionit was extracted
5. stirringby stirring with water
6. customthe organic phase was dried
7. concentrationconcentrated
8. customto give a colorless oil which
9. customcrystallized after trituration with petroleum ether
10. filtrationFiltration with suction
11. waitleft 70.5 g (67.0% of theory) of colorless crystals