反应详情

1.80 g (9 mmol) of ethyl (4-chloropyrimidin-6-yl)acetate, 1.40 g (9 mmol) of cis-4-tert-butylcyclohexylamine and 1.82 g (18 mmol) of triethylamine were heated at 80° to 90° C. for 8 hours. After cooling, the mixture was taken up in water/toluene and the organic phase was dried and concentrated. Purification was carried out by chromatography on silica gel (ethyl acetate) to give 1.85 g (64.4% of theory) of a colorless resin.

1. temperatureAfter cooling
2. customthe organic phase was dried
3. concentrationconcentrated
4. customPurification
5. customto give 1.85 g (64.4% of theory) of a colorless resin