反应详情

A solution of 1.7 g (9.2 mmol) of methyl 4-chloromethylbenzoate in 25 ml of chloroform was added with 10 g (95 mmol) of diethanolamine, followed by heating under reflux for 10 hours. The resulting solution was washed with water and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column (chloroform), whereby 1.5 g of a colorless oil were obtained.

1. temperatureby heating
2. temperatureunder reflux for 10 hours
3. washThe resulting solution was washed with water
4. dry with materialdried over magnesium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customThe residue was purified by chromatography on a silica gel column (chloroform)