Thionyl Chloride → HCID 85981973, compound

HRID 1458682Notes

Reaction equation

HRID 1458682 reaction equation
S(Cl)([Cl:3])=O.[Cl:5][CH2:6][CH2:7][N:8]([CH2:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1)[CH2:9][CH2:10][Cl:11]>C1C=CC=CC=1>[Cl:5][CH2:6][CH2:7][N:8]([CH2:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([Cl:3])=[O:18])=[CH:15][CH:14]=1)[CH2:9][CH2:10][Cl:11]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 425503Benzoic acid, 4-[[bis(2-chloroethyl)amino]methyl]-

Product 1

HCID 85981973HCID 85981973, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
80 °C

Procedure

Thionyl chloride (1 ml) was added to a solution of 320 mg (1.0 mmol) of 4-[N,N-bis(2-chloroethyl)aminomethyl]benzoic acid in 2 ml of benzene, followed by stirring under heating at 80° C. for 2 hours. After the solvent was distilled out under reduced pressure, the residue was dried up under reduced pressure so that a white solid was obtained.

Workup

  1. distillationAfter the solvent was distilled out under reduced pressure
  2. customthe residue was dried up under reduced pressure so that a white solid
  3. customwas obtained

Sources & evidence

ORD record
ord-03b1b8bd10af44afa0107c13917c6dc6
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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