Hydrogen Bromide → Benzoic acid, p-(bis(2-bromoethyl)amino)-

HRID 1458704Notes

Reaction equation

HRID 1458704 reaction equation
[Br:1][CH2:2][CH2:3][N:4]([C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=1)[CH2:5][CH2:6][Br:7].Br>>[Br:1][CH2:2][CH2:3][N:4]([C:8]1[CH:18]=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)[CH2:5][CH2:6][Br:7]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 22096832HCID 22096832, compound

Product 1

HCID 16283Benzoic acid, p-(bis(2-bromoethyl)amino)-Yield 71.2%

Procedure

Ethyl 4-[N,N-bis(2-bromoethyl)amino]benzoate (1.0 g; 2.6 mmol) was added to 10 ml of a 47% aqueous solution of hydrobromic acid, followed by stirring for 30 minutes under heating and reflux. The solvent was distilled out under reduced pressure, whereby 650 mg of white powder were obtained (yield: 70%).

Workup

  1. temperatureunder heating
  2. temperaturereflux
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-55bab2259626444794e1ed154115af49
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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