2-(Ethylamino)ethanol → HCID 22096725, compound

HRID 1458723Notes

Reaction equation

HRID 1458723 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH2:10]([NH:12][CH2:13][CH2:14][OH:15])[CH3:11]>CS(C)=O>[CH2:10]([N:12]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1)[CH2:13][CH2:14][OH:15])[CH3:11]

Participants

4

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 145174-Fluorobenzonitrile

Product 1

HCID 22096725HCID 22096725, compoundYield 21,335.1%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
140 °C

Procedure

A solution of 10 g (82.6 mmol) of 4-fluorobenzonitrile and 15 g (0.17 mmol) of 2-(ethylamino)ethanol in 30 ml of DMSO was stirred under heat at 140° C. for 3 hours, followed by extraction with ethyl acetate. The solvent was distilled out under reduced pressure, followed by washing with ethyl acetate, whereby 6.9 g of white powder were obtained (yield: 44%).

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. distillationThe solvent was distilled out under reduced pressure
  3. washby washing with ethyl acetate

Sources & evidence

ORD record
ord-fe415d2f191c412ea92a4e45fcc88562
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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