反应详情

K2CO3 (13.94 g, 0.101 mol) is dissolved in water (67 ml), and then 2-iodo-4-methoxybenzoic acid (25.3 g, 0.091 mol) is added, followed by 5-amino-1-ethylpyrazole (11.2 g, 0.101 mol) and finally copper (2.7 g). The reaction mixture is refluxed for 20 hours, cooled to room temperature. Then water (350 ml) is added, and the mixture is refluxed for 0.75 hours. The reaction mixture is cooled, and the product is collected by filtration, recrystallized from ethanol, and dried in an oven at 40° C. to afford 13.37 g (56%) of N-(1-ethylpyrazol-5-yl)-4-methoxyanthranilic acid, m.p. 130°-135° C.

1. temperatureThe reaction mixture is refluxed for 20 hours
2. temperaturethe mixture is refluxed for 0.75 hours
3. temperatureThe reaction mixture is cooled
4. filtrationthe product is collected by filtration
5. customrecrystallized from ethanol
6. customdried in an oven at 40° C.