1-(2-Fluorophenyl)piperazine Hydrochloride → 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-fluorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride

HRID 1458978Notes

Reaction equation

HRID 1458978 reaction equation
[ClH:1].[CH3:2][C:3]1[N:7]([C:8]2[N:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:6]=[CH:5][C:4]=1[C:14](=O)[CH2:15][CH2:16][N:17]1[CH2:26][CH2:25]C2[C:19](=CC=CC=2)[CH2:18]1.Cl.CC1N(C2N=CC=CN=2)N=CC=1/C=C/CN1CCC2C(=CC=CC=2)C1.Cl.[F:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=1[N:62]1CCNCC1>>[ClH:1].[CH3:2][C:3]1[N:7]([C:8]2[N:9]=[CH:10][CH:11]=[CH:12][N:13]=2)[N:6]=[CH:5][C:4]=1/[CH:14]=[CH:15]/[CH2:16][N:17]1[CH2:18][CH2:19][N:62]([C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][C:56]=2[F:55])[CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 27346981-(2-Fluorophenyl)piperazine HydrochlorideHCID 220973011-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-propanone hydrochlorideHCID 220973051-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-trans-propene hydrochloride

Product 1

HCID 220973181-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-fluorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride

Procedure

The procedures of Example 6 (1) and (2) were repeated but substituting the 1,2,3,4-tetrahydroisoquinoline hydrochloride employed in Example 6 (1) by 1-(2-fluorophenyl)piperazine hydrochloride. After the completion of the post treatment, the title compound was obtained.

Sources & evidence

ORD record
ord-e63033483fb14930aae074305c232edf
Source dataset
uspto-grants-1998_12
Patent number
US05852019

Reaction notes

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