HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Fluorophenyl)piperazine Hydrochloride → 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-fluorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Fluorophenyl)piperazine Hydrochloride | HCID 2734698 | — |
| Reactant | 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-propanone hydrochloride | HCID 22097301 | — |
| Reactant | 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-trans-propene hydrochloride | HCID 22097305 | — |
| Product | 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-fluorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride | HCID 22097318 | — |
Reaction Steps
The procedures of Example 6 (1) and (2) were repeated but substituting the 1,2,3,4-tetrahydroisoquinoline hydrochloride employed in Example 6 (1) by 1-(2-fluorophenyl)piperazine hydrochloride. After the completion of the post treatment, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05852019 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-e63033483fb14930aae074305c232edf |
| Source note | uspto-grants-1998_12 |