Sodium Iodide → Iodophenylhydrazine

Participants

Reaction Steps

The starting reactant is phenylhydrazine. The hydrazine group is protected, the aromatic ring is nitrated and subsequently, the nitro-product is chromatographed, reduced to amine, reacted with nitrous acid and sodium iodide to give p-iodo-substituted protected phenylhydrazine. Subsequently it is reacted with hexabutylditin and tetrakis (triphenylphosphine)palladium(0) and then with sodium iodide (NaI125) in the presence of such oxidizing agent as Chloramine-T. The final step, deprotection, gives p-I125 -iodophenylhydrazine.

Provenance & Evidence