Formic Acid → HCID 88305077, compound

HRID 1459157Notes

Reaction equation

HRID 1459157 reaction equation
[CH3:1][C@@:2]12[C:10](=[O:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH:13]=[C:14]3[CH2:19][C@@H:18](O)[CH2:17][CH2:16][C@:15]3([CH3:21])[C@H:5]1[CH2:4][CH2:3]2.O.[CH:23]([OH:25])=[O:24]>>[CH:23]([O:25][CH2:1][C@:2]12[CH2:3][CH2:4][C@H:5]3[C@@H:6]([CH2:12][CH:13]=[C:14]4[C@:15]3([CH3:21])[CH2:16][CH2:17][CH2:18][CH2:19]4)[C@@H:7]1[CH2:8][CH2:9][C:10]2=[O:11])=[O:24]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 962WaterHCID 5881Dehydroepiandrosterone

Product 1

HCID 88305077HCID 88305077, compound

Conditions

Temperature
60 °C

Procedure

Following the procedure described by Ringold (H. J. Ringold, et al., J. Am. Chem. Soc. 78, 816, 1956), dehydroepiandrosterone (2.88 g, 10 mmol) dissolved in 85% formic acid (100 mL) is heated at 60° C for 1 h. After cooling, the mixture is poured into iced water and after 16 h, crystals are filtered and dried in vacuo.

Workup

  1. temperatureAfter cooling
  2. filtrationcrystals are filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7e21b028083e48b691554d3fd7b0f716
Source dataset
uspto-grants-1998_12
Patent number
US05854229

Reaction notes

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