HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Methyl-4-(trifluoromethyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine | HCID 2736626 | — |
| Product | 6-Methyl-4-(trifluoromethyl)pyridin-2-amine | HCID 18428521 | — |
Reaction Steps
2-chloro-6-methyl-4-(trifluoromethyl)pyridine (5.0 g) and conc ammonium hydroxide (150 mL) were heated at 180° C. in a steel reaction vessel with mechanical stirring overnight. The contents were allowed to cool and partitioned between CH2Cl2 and water. The CH2 Cl2 layer was dried (MgSO4) and concentrated in vacuo leaving 2-amino-6-methyl-4-(trifluoromethyl)pyridine as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05854234 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-b8be5cce38c14a8ba3b892698ec5132e |
| Source note | uspto-grants-1998_12 |